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pentobarbital will reduce the extent or effect of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or outcome of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Advisable atogepant dosage with concomitant utilization of power